Kaylee Allen
Evaluation of Vulvovaginal Disorders
Dr. Colleen Stockdale presented information about trauma-informed care and its application when evaluating vulvovaginal disorders. First, Stockdale described the principles of trauma-informed care. Trauma may be physical or psychological, including sexual violence, intimate partner violence, adverse childhood experiences, neglect, loss, war and conflict, poverty, community violence, discrimination, medical trauma, and natural disasters. Trauma-informed care is…
Updates in Autoimmune Blistering Disease: Established and Emerging Therapies
Dr. Cory Simpson presented information about the autoimmune blistering diseases pemphigus and pemphigoid, including their pathogenesis, varied clinical presentations, diagnostic work-up, and available and emerging treatment options. First, Simpson described the pathogenesis and clinical presentation of pemphigus and pemphigoid. Both are autoimmune diseases caused by the immune system attacking certain proteins present in the skin…
Defining Novel Druggable Pathways in Darier, Hailey-Hailey, and Grover Disease: From Bedside to Bench and Back
Dr. Cory Simpson presented information about his research identifying novel therapeutic targets for rare skin blistering disorders, including Darier, Hailey-Hailey, and Grover disease. First, Simpson described the clinical features, pathology, and genetics of Darier and Hailey-Hailey disease. Both diseases are autosomal dominant with adolescent onset. They may present with flaccid blisters, crusted erosions, and fissured…
Tough Decisions for Longitudinal Melanonychia: Approach to Evaluation, Sampling, and Laboratory Processing
Dr. Adam Rubin presented information about the clinical presentation and biopsy collection of longitudinal melanonychia. Most cases of nail unit melanoma (NUM) present as longitudinal melanonychia. NUM has a higher mortality rate compared with other cutaneous melanomas due to delayed diagnosis and more advanced disease on presentation. First, Rubin described the clinical presentation of longitudinal…
Nailing the Red Streak: Evaluation of Erythronychia and Novel Insights
Dr. Adam Rubin presented information about the clinical presentation, histopathology, and differential diagnosis of longitudinal erythronychia. The differential diagnosis of longitudinal erythronychia includes onychopapilloma, nail unit acantholytic dyskeratotic acanthoma, glomus tumor, symplastic glomus tumor, arteriovenous malformation, subungual leiomyoma, amelanotic melanoma, and nail unit squamous cell carcinoma. Polydactylous erythronychia may indicate systemic disease. First, Rubin discussed…
From Human Biology to Precision Medicine
When Thomas Leung, MD, PhD, walked into his postdoctoral laboratory at Stanford University (Stanford) on his first day, he was surprised to discover that graduate students in a neighboring lab already knew who he was. Their principal investigator, a former lab mate, had been sharing a story about him. As a graduate student, Leung had…
Organoids, CRISPR, and a Shortcut to Therapies for Rare Blistering Diseases
Blistering skin diseases cause a great deal of ongoing suffering. Their characteristic surface wounds cause pain, itching, and infections, and conventional treatments, including topical and oral corticosteroids, provide temporary, limited relief. For autoimmune blistering diseases, like pemphigus vulgaris, monoclonal antibodies (e.g., rituximab) promise longer-lasting relief, while CAAR-T cell therapy that targets B cell-mediated autoimmune diseases is a promising development…
Remembering James O. Ertle, MD
James O. Ertle, MD was a steadfast and longstanding member of the Dermatology Foundation for forty years. He was a deeply respected leader in dermatology. A prolific fundraiser with an abiding belief in the Foundation’s mission — he was an Annenberg Sustaining and Visionary Society member — he will also be remembered for his many…
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