Education
Cutting-edge talks from today’s specialty experts attract attendees to the DF’s annual CME meeting: Clinical Symposia—Advances in Dermatology.
Off to the Races: Engineering CA(A)R-T Cells for Skin Disease Therapy
CAR T cell therapy is a personalized immunotherapy technology. A patient’s T cells are collected, genetically altered to express chimeric antigen receptors, and reinfused. CAR T cells seek out and kill target cells that express the specified antigen, such as CD19 or B cell maturation antigen (BCMA). Additionally, CAR T cells are programmed to proliferate and produce memory CAR T cells in the presence of target cells. Ongoing research into chimeric antigen receptor (CAR) T cell therapy and chimeric autoantibody receptor (CAAR) T cell therapy for cancers and autoimmune diseases, including pemphigus vulgaris (PV) may lead to clinical trials.
Don’t Miss it! Important Skin Diseases in Children
There are rare but important causes of neonatal blistering, diaper rash, and solitary skin nodules. Incontinentia pigmenti (IP), for example, is an X-linked dominant disorder affecting the skin, eyes, and central nervous system. IP is suspected when blisters occur in a blaschkoid distribution. Because IP is lethal in males, presentation of a female patient whose mother has a history of miscarriages can indicate this disease. IP can be diagnosed based solely on rash and skin biopsy results, without genetic testing. Early diagnosis and treatment can significantly reduce morbidity and mortality by preventing seizures and promoting development.
Top 10 Tips for Treating Skin Disease in Children with Cancer
Children with melanoma may present with different clinical characteristics than adults. They are more likely to present as amelanotic, rapidly growing nodules. Incorporate modified diagnostic criteria for pediatric melanoma and consider the evolution of a lesion. Pediatric melanoma is rare but often diagnosed too late.
Updates in Pustular Psoriasis
Pustular psoriasis is a group of inflammatory skin diseases characterized by visible, sterile pustules on inflamed skin. It appears in generalized and localized forms and can occur in patients with or without a history of psoriasis. Pustular psoriasis has distinct genetic risk factors, inflammatory profile, and response to treatment compared to psoriasis. Thus, it may be its own unique disease. PPP is characterized by sterile pustules on the palms and soles. There is no consensus on optimal treatment , although acitretin, methotrexate, and phototherapy are among the more common treatments.
Evidence-Based Vaccine Recommendations for Dermatology Patients
Although vaccines are typically discussed in primary care settings, dermatologists have an important role in vaccine education, especially when prescribing immunosuppressive medications that can increase risk of infections. Infections are more common in patients with chronic skin diseases due to disruption of the protective skin barrier, immune dysregulation associated with disease, and immunosuppressive treatments.
The Melanoma Epidemic: Real or Illusory
In 2023, the United States Preventive Services Task Force determined there was insufficient evidence to assess the balance of benefits and harms of screening for melanoma using a whole-body skin examination in the primary care setting in part due to the lack of randomized controlled studies. Such studies addressing the mortality benefit of screening for skin cancer would be a massive undertaking. On a practical level, there are not enough dermatologists in the country to screen all American adults for skin cancer.
Skin Cancer Disparities in Patients with Skin of Color
The incidence of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma is significantly lower in darker skin types. In Black people, BCC is 2000-fold less common, and SCC is 500–1000-fold less common compared to non-Hispanic white people. Melanoma-related mortality rates in the US-based Black population has been declining during the past 20 years. Non-white race is associated with later melanoma detection and lower survival rates. Multiple risk factors have been proposed for skin cancers in skin of color including immunosuppression and previous scaring. More research is needed to understand the primary drivers of skin cancer in skin of color.
2023 DF Annual Meeting
New Orleans is renowned for its music, food, and joie de vivre. And now it can add the Dermatology Foundation’s Annual Meeting of Membership to its roster of attractions. The Big Easy was host to an event where people reconnect, acknowledge the year’s successes, and celebrate the people who have received Foundation support.
2023 DF Clinical Symposium
The DF Clinical Symposium is the national medical education event that attracts dermatologists, residents, and non-physician clinicians seeking a serious, in-depth educational experience. In its 20th year, this peer-reviewed continuing medical education program delivers cutting-edge talks from today’s specialty experts on every aspect of dermatology.
Mohs for Melanoma
Dr. Bordeaux’s key takeaway message is that Mohs decreases the local recurrence of melanoma and helps reduce the number of re-excisions that patients undergo due to positive margins