precision medicine
Defining Novel Druggable Pathways in Darier, Hailey-Hailey, and Grover Disease: From Bedside to Bench and Back
Dr. Cory Simpson presented information about his research identifying novel therapeutic targets for rare skin blistering disorders, including Darier, Hailey-Hailey, and Grover disease. First, Simpson described the clinical features, pathology, and genetics of Darier and Hailey-Hailey disease. Both diseases are autosomal dominant with adolescent onset. They may present with flaccid blisters, crusted erosions, and fissured…
From Human Biology to Precision Medicine
When Thomas Leung, MD, PhD, walked into his postdoctoral laboratory at Stanford University (Stanford) on his first day, he was surprised to discover that graduate students in a neighboring lab already knew who he was. Their principal investigator, a former lab mate, had been sharing a story about him. As a graduate student, Leung had…
Precision Medicine in Cutaneous Lymphoma
Dr. Jaehyuk Choi presented two patient cases that demonstrate his approach to precision medicine in cutaneous lymphoma. Patients are referred to Dr. Choi from multiple institutions to better understand their disease and drivers of therapeutic resistance. He uses machine learning algorithms to identify predictive biomarkers and develop innovative next-generation therapies. Case #1 A 64-year-old male…