MEK inhibition
Defining Novel Druggable Pathways in Darier, Hailey-Hailey, and Grover Disease: From Bedside to Bench and Back
Dr. Cory Simpson presented information about his research identifying novel therapeutic targets for rare skin blistering disorders, including Darier, Hailey-Hailey, and Grover disease. First, Simpson described the clinical features, pathology, and genetics of Darier and Hailey-Hailey disease. Both diseases are autosomal dominant with adolescent onset. They may present with flaccid blisters, crusted erosions, and fissured…